Search results for "evolution [Galaxies]"
showing 10 items of 84 documents
Genetic Variability of Hepatitis C Virus before and after Combined Therapy of Interferon plus Ribavirin
2008
We present an analysis of the selective forces acting on two hepatitis C virus genome regions previously postulated to be involved in the viral response to combined antiviral therapy. One includes the three hypervariable regions in the envelope E2 glycoprotein, and the other encompasses the PKR binding domain and the V3 domain in the NS5A region. We used a cohort of 22 non-responder patients to combined therapy (interferon alpha-2a plus ribavirin) for which samples were obtained before initiation of therapy and after 6 or/and 12 months of treatment. A range of 25-100 clones per patient, genome region and time sample were sequenced. These were used to detect general patterns of adaptation, t…
Genomic instability in an interspecific hybrid of the genus Saccharomyces: a matter of adaptability
2020
Ancient events of polyploidy have been linked to huge evolutionary leaps in the tree of life, while increasing evidence shows that newly established polyploids have adaptive advantages in certain stress conditions compared to their relatives with a lower ploidy. The genus Saccharomyces is a good model for studying such events, as it contains an ancient whole-genome duplication event and many sequenced Saccharomyces cerevisiae are, evolutionary speaking, newly formed polyploids. Many polyploids have unstable genomes and go through large genome erosions; however, it is still unknown what mechanisms govern this reduction. Here, we sequenced and studied the natural S. cerevisiae × Saccharomyces…
Evidence of Recombination in Intrapatient Populations of Hepatitis C Virus.
2008
Hepatitis C virus (HCV) is a major cause of liver disease worldwide and a potential cause of substantial morbidity and mortality in the future. HCV is characterized by a high level of genetic heterogeneity. Although homologous recombination has been demonstrated in many members of the family Flaviviridae, to which HCV belongs, there are only a few studies reporting recombination on natural populations of HCV, suggesting that these events are rare in vivo. Furthermore, these few studies have focused on recombination between different HCV genotypes/subtypes but there are no reports on the extent of intra-genotype or intra-subtype recombination between viral strains infecting the same patient.…
Improving High Frequency Transformers behavior for DC-DC Converter Used in Electric Vehicles
2018
The paper presents a design procedure for high frequency transformer windings adopted in the DC-DC converter used in electric vehicles. The output of the design procedure is the integration of a 3D printed plastic case in the transformer windings, with the aim to maximize the output power. The proposal design procedure is entirely based on a finite element analysis approach and on a differential evolution algorithm used for the solution of the optimization problem.
Identification of novel, clonally stable, somatic mutations targeting transcription factors PAX5 and NKX2-3, the epigenetic regulator LRIF1, and BRAF…
2021
Diagnosis of B-cell chronic lymphocytic leukemia (B-CLL) is usually straightforward, involving clinical, immunophenotypic (Matutes score), and (immuno)genetic analyses (to refine patient prognosis for treatment). CLL cases with atypical presentation (e.g., Matutes ≤ 3) are also encountered, and for these diseases, biology and prognostic impact are less clear. Here we report the genomic characterization of a case of atypical B-CLL in a 70-yr-old male patient; B-CLL cells showed a Matutes score of 3, chromosomal translocation t(14;18)(q32;q21) (BCL2/IGH), mutated IGHV, deletion 17p, and mutations in BCL2, NOTCH1 (subclonal), and TP53 (subclonal). Quite strikingly, a novel PAX5 mutation that w…
A multi-parametric evolution strategies algorithm for vehicle routing problems
2007
Vehicle routing problems are at the heart of most decision support systems for real-life distribution problems. In vehicle routing problem a set of routes must be determined at lowest total cost for a number of resources (i.e. fleet of vehicles) located at one or several points (e.g. depots, warehouses) in order to efficiently service a number of demand or supply points. In this paper an efficient evolution strategies algorithm is developed for both capacitated vehicle routing problem and for vehicle routing problem with time window constraints. The algorithm is based on a new multi-parametric mutation procedure that is applied within the 1 + 1 evolution strategies algorithm. Computational …
On multi-objective optimal reconfiguration of MV networks in presence of different grounding
2015
The present work faces the traditional multi-objective optimal reconfiguration problem of a distribution grid including the safety issue in the objective functions. Actually, in many medium voltage networks still transformers with ungrounded neutral and with resonant grounded neutral coexist in the same area. This may be sometimes cause of problems during a single-line-to-ground fault if the ground electrodes of one or more cabins, initially designed for satisfying the safety conditions in a resonant grounded neutral network, after the reconfiguration are in a grounded neutral one or vice versa. In the paper a safety objective function is defined and the Non dominated Sorting Genetic Algori…
Memetic Algorithms in Engineering and Design
2012
When dealing with real-world applications, one often faces non-linear and nondifferentiable optimization problems which do not allow the employment of exact methods. In addition, as highlighted in [104], popular local search methods (e.g. Hooke-Jeeves, Nelder Mead and Rosenbrock) can be ill-suited when the real-world problem is characterized by a complex and highly multi-modal fitness landscape since they tend to converge to local optima. In these situations, population based meta-heuristics can be a reasonable choice, since they have a good potential in detecting high quality solutions. For these reasons, meta-heuristics, such as Genetic Algorithms (GAs), Evolution Strategy (ES), Particle …
Evolving non-dominated solutions in multiobjective service restoration for automated distribution networks
2001
Abstract The problem here dealt with is that of Service Restoration (SR) in automated distribution networks. In such networks, configuration and compensation level as well as loads insertion status can be remotely controlled. The considered SR problem should be handled using Multiobjective Optimization, MO, techniques since its solution requires a compromise between different criteria. In the adopted formulation, these criteria are the supply of the highest number of loads and the minimum power losses. The Authors propose a new MO approach, the Non-dominated Sorting Fuzzy Evolution Strategy, NS_FES, which uses part of the Non-dominated Sorting Genetic Algorithm, NSGA, proposed by K. Deb. Th…
Cancer Clonal Evolution and Intra-tumor Heterogeneity
2017
Despite recent advances in understanding cancer onset mechanisms and development of new therapeutic approaches, however, the resistance of tumor cells to different therapies represents the main obstacle to the successful treatment, resulting in poor prognosis and tumor recurrence. Currently, understanding the causes underlying this resistance is the main objective of oncology research in recent years. Tumors are not uniform diseases but heterogeneous entities consisting of cell populations called clones, with different genetic and molecular characteristics. Indeed, most of cancers shows usually a single clonal origin at the early stages of the disease, but, in advanced stages, tumors may in…